Abstract
The findings of the prior studies investigating the resistin levels in
Crohn’s disease (CD) patients and ulcerative colitis (UC) patients are
inconsistent. Hence we performed the meta-analysis to systematically
evaluate the serum levels of resistin in CD and UC, as well as in
healthy individuals. PubMed, Web of Science, Embase, Cochrane Library
and Chinese National Knowledge Infrastructure (CNKI) (as of April 30,
2020) were searched to collect all relevant published articles. We
calculated the pooled standard mean difference (SMD) and 95% confidence
interval (CI) by R software. Eight articles including 438 CD patients
and 358 controls, and 9 articles including 391 UC patients and 438
controls were enrolled. The results showed that resistin levels were
significantly elevated in patients with CD (SMD = 1.76, 95% CI: 0.64 to
2.88, p = 0.002) and UC (SMD = 2.10, 95% CI: 1.03 to 3.17, p
< 0.001) compared with healthy controls. Our findings indicate
that the elevated levels of serum resistin were associated with CD and
UC.