Figure 4. Promising therapeutic drugs that inhibit the progress
of SMPP
(A) Bar plot of candidate perturbations inferred from connectivity map
analysis. Top 10 compounds with most positive and negative connectivity
score are showed. (B) CMap mode-of-action (MoA) analysis under the
selected 25 drugs whose connectivity scores less than -70. Potential
mechanisms and inhibitors are placed on the right and the top panel. The
perturbations’ mode of actions are indicated with black dots. (C)
CMap gene target analysis under the
selected 25 drugs. Identified target genes and inhibitors are placed on
the right and top panel. The perturbations’ target genes are indicated
with black dots. (D) Protein-protein interaction network of the target
genes inferred from CMap gene target analysis. The relationships between
these proteins are inferred from STRING.