2.6 Predication of transcription factors (TFs) regulating FCGBP
We used Cistrome Data Browser toolkit (http://dbtoolkit.cistrome.org/)11to predicate potential TFs that regulating targeted protein FCGBP. Cistrome Data Browser is a user-friendly web server for querying, exploring and visualizing ChIP-Seq and chromatin accessibility data. Since few ChIP-Seq data were publicly available in BEAS-2B cells, an epithelial cell line isolated from normal human bronchial epithelium, we query FCGBP’s potential TFs in all available lung cells including A549, BEAS-2B and NCI-H2052 under the setting of 100 kb distance to transcription start site in order to include enhancer-type TFs.