Figure 4. Promising therapeutic drugs that inhibit the progress of SMPP
(A) Bar plot of candidate perturbations inferred from connectivity map analysis. Top 10 compounds with most positive and negative connectivity score are showed. (B) CMap mode-of-action (MoA) analysis under the selected 25 drugs whose connectivity scores less than -70. Potential mechanisms and inhibitors are placed on the right and the top panel. The perturbations’ mode of actions are indicated with black dots. (C) CMap gene target analysis under the selected 25 drugs. Identified target genes and inhibitors are placed on the right and top panel. The perturbations’ target genes are indicated with black dots. (D) Protein-protein interaction network of the target genes inferred from CMap gene target analysis. The relationships between these proteins are inferred from STRING.