Trial design
This was a prospective, single-center, RCT. A total of 955 patients with KD at the Department of Cardiology of Guangzhou Women and Children’s Medical Center fromJanuary 2018 toJune 2019 were selected and were initially treated with IVIG. 80 patientswho were assessed as IVIGresistant were randomly divided into two groupsusing a random number table. TheResearch Ethics Committee of Guangzhou Women and Children’s Medical Centerapprovedthis study (NO. GZR2015-099), and the children and their families provided their written informed consent.The registration number of this randomized controlled clinical trial is: ChiCTR-EOC-17013266.