Clinical Applicability of the Study
Overall, most studies do not show a significant benefit of ESS on pulmonary outcomes in CF patients. This may be due to a lack of consensus regarding type of surgery offered (full ESS vs uncinectomy/maxillary antrostomy), immediate post-operative sinonasal regime (i.e. duration of IV/oral antibiotic therapy and topical management), appropriate patient selection (mutation type, lung transplantation status, etc.) and frequency of long-term follow-up with management of sinonasal exacerbations. Interestingly, in our study, we identified an increase in the total number of days hospitalized post-operatively. This may be due to the fact that we are performing surgical intervention on patients with more severe disease and the natural course of their disease leads to an increased total number of days hospitalized.