Study Population
All cystic fibrosis patients over the age of 19 evaluated at ’[removed
for blind peer review]’.were included in the review. Patients were
included if they held a diagnosis of with CF (positive sweat chloride
test +/- genetic phenotype testing) and diagnosis of chronic
rhinosinusitis (CRS) (with/without polyposis) based on the Canadian
Rhinosinusitis Guidelines (may include radiologic or endoscopic findings
of CRS) [15]. Patients were excluded if they had prior lung
transplantation or were diagnosed with sinonasal tumors. 100 patients
were reviewed, 40 were included in the study. A significant number of
patients had missing data points including date of surgery or FEV1
levels.
All surgical patients underwent computer-assisted endoscopic sinus
surgery, consisting of bilateral maxillary antrostomy, anterior and
posterior ethmoidectomy, sphenoidotomy, and frontal sinusotomy (when
present). None of the patients were treated with topical inhaled
antibiotics.
Patients in the surgical group (n=20) were matched 1:1 to non-surgical
counterparts based on the covariates of gender, age, and mutation
(F508del homozygous vs heterozygous). Although initially approximately
100 patients were reviewed, Once matched, FEV-1 % predicted 1-year
pre-surgical date, FEV-1% predicted 1-year post-surgical date, and
FEV-1% predicted 2-years post-surgical date were identified. The total
number of pulmonary exacerbations and the total number of days
hospitalized 2 years pre and 2 years post-surgical date were identified
and recorded.