Study Population
All cystic fibrosis patients over the age of 19 evaluated at ’[removed for blind peer review]’.were included in the review. Patients were included if they held a diagnosis of with CF (positive sweat chloride test +/- genetic phenotype testing) and diagnosis of chronic rhinosinusitis (CRS) (with/without polyposis) based on the Canadian Rhinosinusitis Guidelines (may include radiologic or endoscopic findings of CRS) [15]. Patients were excluded if they had prior lung transplantation or were diagnosed with sinonasal tumors. 100 patients were reviewed, 40 were included in the study. A significant number of patients had missing data points including date of surgery or FEV1 levels.
All surgical patients underwent computer-assisted endoscopic sinus surgery, consisting of bilateral maxillary antrostomy, anterior and posterior ethmoidectomy, sphenoidotomy, and frontal sinusotomy (when present). None of the patients were treated with topical inhaled antibiotics.
Patients in the surgical group (n=20) were matched 1:1 to non-surgical counterparts based on the covariates of gender, age, and mutation (F508del homozygous vs heterozygous). Although initially approximately 100 patients were reviewed, Once matched, FEV-1 % predicted 1-year pre-surgical date, FEV-1% predicted 1-year post-surgical date, and FEV-1% predicted 2-years post-surgical date were identified. The total number of pulmonary exacerbations and the total number of days hospitalized 2 years pre and 2 years post-surgical date were identified and recorded.