Clinical Applicability of the Study
Overall, most studies do not show a significant benefit of ESS on
pulmonary outcomes in CF patients. This may be due to a lack of
consensus regarding type of surgery offered (full ESS vs
uncinectomy/maxillary antrostomy), immediate post-operative sinonasal
regime (i.e. duration of IV/oral antibiotic therapy and topical
management), appropriate patient selection (mutation type, lung
transplantation status, etc.) and frequency of long-term follow-up with
management of sinonasal exacerbations. Interestingly, in our study, we
identified an increase in the total number of days hospitalized
post-operatively. This may be due to the fact that we are performing
surgical intervention on patients with more severe disease and the
natural course of their disease leads to an increased total number of
days hospitalized.