Strengths and Limitations
The cornerstones of the study are the national scale of the data collection alongside its population-based approach, the wealth of information garnered, and the opportunity to verify the data from the onset of the epidemic. Another asset is the gathering of data on cases of infection in the first trimester of pregnancy, which has not yet been described in the literature. Weak points include the analysis of preliminary data while disease transmission is still occurring, which limits the completeness of the study cohort and does not allow robust evaluation of all the variables under scrutiny. Data generalizability must take into account the prevalence of the condition in the different geographical areas and the characteristics of the population under study.