Strengths and Limitations
The cornerstones of the study are the national scale of the data
collection alongside its population-based approach, the wealth of
information garnered, and the opportunity to verify the data from the
onset of the epidemic. Another asset is the gathering of data on cases
of infection in the first trimester of pregnancy, which has not yet been
described in the literature. Weak points include the analysis of
preliminary data while disease transmission is still occurring, which
limits the completeness of the study cohort and does not allow robust
evaluation of all the variables under scrutiny. Data generalizability
must take into account the prevalence of the condition in the different
geographical areas and the characteristics of the population under
study.