Author Contributions
X. L.performed ATPase assay, PTS assay, pull-down, and Western-blot analysis, mouse behavioral experiments, corresponding data analysis and wrote the manuscript. Y. Z. contributed to manuscript writing and modifying, and was involved in mouse behavioral experiments. Y.F. contributed to HTRF assay, neuronal loss and apoptosis measurement. H. Z. contributed to simulating the interaction model of gossypol acetate and VCP. H. L. completed Drosophila model behavior experiments. Q. L. was involved in the Western-blot analysis. H. L. was involved in the mouse behavioral experiments. R. T. conducted the HTS. C. J. performed partially proteolysis assay and ITC experiment. W. J. and Z. L. involved in proteins expression and purification, ITC and the mouse behavioral experiments. C. L. conceived and supervised simulation of the interaction model. B. L. conceived and supervised HD cell and animal experiments. Y. D. conceived and supervised the project and modified the manuscripts.