Author Contributions
X. L.performed ATPase assay, PTS assay, pull-down, and Western-blot
analysis, mouse behavioral experiments, corresponding data analysis and
wrote the manuscript. Y. Z. contributed to manuscript writing and
modifying, and was involved in mouse behavioral experiments. Y.F.
contributed to HTRF assay, neuronal loss and apoptosis measurement. H.
Z. contributed to simulating the interaction model of gossypol acetate
and VCP. H. L. completed Drosophila model behavior experiments. Q. L.
was involved in the Western-blot analysis. H. L. was involved in the
mouse behavioral experiments. R. T. conducted the HTS. C. J. performed
partially proteolysis assay and ITC experiment. W. J. and Z. L. involved
in proteins expression and purification, ITC and the mouse behavioral
experiments. C. L. conceived and supervised simulation of the
interaction model. B. L. conceived and supervised HD cell and animal
experiments. Y. D. conceived and supervised the project and modified the
manuscripts.