Challenges in management of Severe Hemophilia with Acute Hematologic
Approximately 13 patients with hemophilia A or B have been reported to
be diagnosed with acute leukemia in childhood [1, 2]. This rarity
appeared again in a 13 year old male with severe hemophilia with
inhibitors who presented with worsening bone pain, weight loss, and
leukocytosis. Coexistence of these life-threatening disorders,
hemophilia and acute leukemia, pose practical challenges in providing
standard care as the former has a propensity of bleeding and the latter
requires intensive treatment with systemic and intrathecal chemotherapy.
Our discussion aims at highlighting critical care strategies in
management of severe hemophilia and hematologic malignancies.