4.1 Limitations
This study has several limitations. The most important limitation is that it had a small sample size. It was a single centre trial and we chose to only use data from the same 3D TEE system. We did not compare clinical outcomes such as MACE and mortality or measurable echocardiography parameters such as the presence/severity of PVAR, as 3D TEE was not solely used as the imaging modality for deciding which TAVR prosthesis would be implanted. Our findings are not generalisable to other manual or semi-automated 3D TEE techniques/software other than the methods that we used.