Primary efficacy endpoint
Regarding the arrhythmic recurrence, multivariate Cox survival analysis
identified ES at presentation, NYHA class III or IV, LVEF, IHD and C-ABL
as in independent predictors of relapse (table 2). The VT-free survival
improvement was only statistically significant in patients with a
previous ablation procedure (P for interaction = 0.003) in sub-group
analysis. This finding was consistent in both IHD and NICM patients (P
for interaction = 0.170). In patients undergoing two or more procedures
C-ABL (HR=0.36, 95%CI 0.17─0.80, P=0.011) and ES (HR=2.42, 95%CI
1.24─4.70, P=0.009) were the only independent predictors of arrhythmia
recurrence.