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A clustering analysis by Poole et al.,27 reported 70 genes expression distinguished TH2-high and TH2-low subjects, including IL13, IL5, Periostin, CLCA1, and SERPINB2. Compared with TH2-low subjects, TH2-high persons were more likely to be a topic, atopic asthma\sout, rhinitis, and elevated serum eosinophil counts. They stated that both atopy status and eosinophilic blood levels were closely related to TH2-high pattern of nasal gene expression, regardless of asthma status. These finding indicated that TH2 activation of atopic or systemically allergic airway is a part of the physiological foundation of asthma. Identifying of TH2-high subjects on the basis of nasal brushings is possible and may have a huge effect on both biomedical and clinical research