Conclusion:
Our findings suggested the vital role of nasal airways epithelial cells
in the pathogenesis of asthma by their differential gene
expression in different asthma
groups. Herein, TMEM178
expression gained attention as a
predictor of asthma severity suggesting its significant value in the
discrimination between different asthma phenotypes. CLCA1, SERPINB2 and
Periostin expression were upregulated in airway epithelial cells of
asthmatic children, however; no significant differences between
different groups of asthma severity were observed. Regarding to asthma
control level, TMEM178, CLCA1, SERPINB2 and Periostin were significantly
up regulated in controlled group compared to partially to uncontrolled
asthma group. Whereas, FKBP5 was upregulated in
partially to uncontrolled
asthma group. Regarding to atopic
status, CLCA1, SERPINB2 and Periostin were significantly up regulated in
atopic than non-atopic asthma while TMEM178 and FKBP5 showed no
statistically significant differences between atopic and non-atopic
asthma.
V: Acknowledgement: NO