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A clustering analysis by Poole et al.,27 reported 70 genes expression distinguished
TH2-high and TH2-low subjects, including IL13, IL5, Periostin, CLCA1,
and SERPINB2. Compared with TH2-low subjects, TH2-high persons were more
likely to be a topic, atopic asthma\sout, rhinitis, and elevated serum
eosinophil counts. They stated that both atopy status and eosinophilic
blood levels were closely related to TH2-high pattern of nasal gene
expression, regardless of asthma status. These finding indicated that
TH2 activation of atopic or systemically allergic airway is a part of
the physiological foundation of asthma. Identifying of TH2-high subjects
on the basis of nasal brushings is possible and may have a huge effect
on both biomedical and clinical research