Key Messages
Rs41423247 (G/C) of the NR3C1 gene was found to be inversely associated with hypothalamic-pituitary-adrenal axis suppression (HPAS) in asthmatic children on steroids. The CC genotype is associated with the highest ACTH levels. If confirmed, the CC genotype could well be a marker of HPAS protection, thereby allowing for personalized treatment decisions to be made in asthma care.