2.2 Data extraction and quality assessment
Information was carefully extracted from all eligible publications by
two independent authors, including author’s name publication date,
country, sample size, plasma concentration and adjusted serum
concentration of CDRCBZ, CDRCBZE and
CDRCBZD, CDRCBZE :
CDRCBZ and CDRCBZD :
CDRCBZE ratios, genotypes distribution, drug resistant
patients (defined as no change or less than 50% reduction in seizure
frequency for at least 1 year during treatment with CBZ and drug
responsive patients defined as seizure-free or a 50% or greater
reduction in seizure frequency for at least 1 year during treatment with
CBZ) [8, 19]. If diverse results were generated the disagreement was
resolved by discussion between the two authors or by asking a third
investigator. The authors of the studies were contacted for additional
data when necessary and applicable.