3.2.2 Associations between ABCB1
(c.3435C>T), EPHX1 (c.337T>C and
c.416A>G), SCN1A (c.3184A>G and
IVS5-91G>A) polymorphisms and CBZ resistance.
For ABCB1
c.3435C>T polymorphism, a total of 344 CBZ resistance and
458 CBZ responsive in 5 studies [8, 22, 27, 29, 30] were included in
this meta-analysis. A statistically significant association was found in
the (CT vs TT) and (CC+CT vs TT) model (OR = 1.603
(95% CI: 1.119~2.298), P = 0.010; OR = 1.61 (95% CI:
1.148~2.258), P = 0.006, respectively) (Table 4) (Fig.
4). There is no associations between other genetic models in ABCB1
C.3435C>T polymorphism and CBZ resistance (Table 4).
For EPHX1 c.337T>C and c.416A>Gpolymorphisms, a total of 113 CBZ resistance and 233 CBZ responsive in 3
studies [7, 8, 25] were included in this meta-analysis with no
associations in any genetic models of EPHX1 c.337T>Cand c.416A>G polymorphisms for CBZ resistance. The
same results were also observed in all genetic models SCN1A
c.3184A>G [8, 13, 24, 26] (4 studies including 430 CBZ
resistance and 597 CBZ responsive) and IVS5-91G>A[8, 14, 23, 24, 26, 28] (6 studies including 612 CBZ resistance and
648 CBZ responsive) (Table 4).