Conclusion
Our results showed that ABCB1 c.3435C>T polymorphism was associated with adjusted concentrations of CBZ and drug-resistance, and EPHX1 c.416A>G polymorphism was related to decrease CBZD concentration, which confirmed important effects ofABCB1 c.3435C>T and EPHX1 c.416A>G gene on pharmacokinetics and pharmacodynamics of CBZ and would help improve individualized therapy of in epilepsy patients.