Conclusion
The administration of VD plus DAG attenuated the fat deposit and body weight gain induced by feeding a high-fat die in rats. The administration of VD plus DAG improve the expression of FAS and CPT1 genes in the liver of obese mice, promote the activation of fatty acids into fatty acyl CoA and enter the mitochondria for oxidative decomposition, thereby reducing the content of TG and TC in the body and improving liver metabolism.Besides, the change in the microbial diversity by VD and DAG was modulated towards the profile in the non-obesity group. Through this study, we found that VD combined with DAG has a significant improvement effect on obese rats,therefore, further research is needed to explore the mechanisms on ameliorates obesity by DAG and VD.