Conclusion
The administration of VD plus DAG attenuated the fat deposit and body
weight gain induced by feeding a high-fat die in rats. The
administration of VD plus DAG improve the expression of FAS and CPT1
genes in the liver of obese mice, promote the activation of fatty acids
into fatty acyl CoA and enter the mitochondria for oxidative
decomposition, thereby reducing the content of TG and TC in the body and
improving liver metabolism.Besides, the change in the microbial
diversity by VD and DAG was modulated towards the profile in the
non-obesity group. Through this study, we found that VD combined with
DAG has a significant improvement effect on obese rats,therefore,
further research is needed to explore the mechanisms on ameliorates
obesity by DAG and VD.