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\begin{document}

\title{Severe ocular and risk organ involvement in a newborn with Langerhans
Cell Histiocytosis}



\author[1]{Alice Brambilla}%
\author[1]{Francesco Pegoraro}%
\author[1]{Maria Luisa Coniglio}%
\author[1]{Roberto Caputo}%
\author[1]{Anna Perrone}%
\author[1]{Anna Maria Buccoliero}%
\author[1]{Claudio Favre}%
\author[1]{Elena Sieni}%
\affil[1]{Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer}%


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  \date{May 08, 2024}


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\begin{abstract}
Langerhans Cell Histiocytosis (LCH) is a rare proliferative disease of
the mononuclear phagocyte system, characterised by tissue infiltration
of CD1a+ CD207+ histiocytes. The clinical presentation is variable,
ranging from unifocal asymptomatic bone involvement to life-threatening
multisystem disease, requiring aggressive therapeutic approaches.
Intraocular involvement is uncommon and associated to poor visual and
general prognosis. Herein, we report a case of LCH in a newborn with
ocular and multisystem risk organ involvement, unresponsive to several
lines of chemotherapy. Off-label administration of vemurafenib led to
dramatic improvement at systemic level; however, chronic sequelae of
ocular involvement resulted in poor visual prognosis.%
\end{abstract}%



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