Fig. 4. Protective efficacy of Cap-3M2e VLPs against IAV.
Immunized mice were challenged with lethal dose of IAV at 64 dpi. Mice
body weight and survival rate changes were monitored daily for 14 days.
(a) Mice body weight changes (n=5), (b) survival rate (n=5) and (c) lung
virus titers (n=4) post 10 × LD50 of A/Puerto
Rico/8/1934 (H1N1) challenge. (d) Mice body weight changes (n=5), (e)
survival rate (n=5) and (f) lung virus titers (n=4) post 10 ×
LD50 of A/swine/Zhucheng/90/2014 (H1N1) challenge. (g)
Mice body weight changes (n=5), (h) survival rate (n=5) and (i) lung
virus titers (n=4) post 40 µL 109TCID50/mL of A/chicken/Guangzhou/GZ/2005 (H9N2)
challenge. p < 0.05 (*).