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Challenges and prospects of COVID-19 vaccine development based on the progress made in SARS and MERS vaccine development
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  • JUBEDA BEGUM,
  • Nasir Akbar Mir,
  • Kapil Dev,
  • Bidyarani Buyamayum,
  • Mohd Yaqoob Wani,
  • Meesam Raza
JUBEDA BEGUM
Govind Ballabh Pant University of Agriculture & Technology College of Veterinary & Animal Sciences
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Nasir Akbar Mir
Central Avian Research Institute
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Kapil Dev
Central Avian Research Institute
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Bidyarani Buyamayum
Jawaharlal Nehru Institute of Medical Sciences Department of Microbiology
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Mohd Yaqoob Wani
Sher-E-Kashmir University of Agricultural Sciences and Technology Faculty of Veterinary Sciences and Animal Husbandry
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Meesam Raza
Central Avian Research Institute
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Peer review status:UNDER REVIEW

20 May 2020Submitted to Transboundary and Emerging Diseases
21 May 2020Assigned to Editor
21 May 2020Submission Checks Completed
23 May 2020Reviewer(s) Assigned
10 Jul 2020Review(s) Completed, Editorial Evaluation Pending

Abstract

The outbreak of COVID-19 as a pandemic has shaken the global health system and economy by their roots. This epidemic is still spreading and showing no signs of decreasing trend. Vaccination is the only effective and economical means to control this pandemic. A number of research institutions and pharmaceutical companies have plunged into the race of vaccine development against COVID-19 which are in various stages of development. An intriguing fact of coronavirus infections is that in every decade of 21st century there is a new major coronavirus epidemic viz. SARS in 2002, MERS in 2012, and now COVID-19; and such epidemics are expected in future too. Since, maximum biological characteristics of SARS-CoV-2 are still obscure the scientists are relying on the information available on SARS-CoV and to some extent on MERS-CoV for designing and development of COVID-19 vaccines. But there is a need of vigorous testing for immunogenicity, safety, efficacy, and level of protection conferred in the hosts. This review focuses on the challenges and prospects of vaccine development against COVID-19. It highlights seriousness, bottlenecks in vaccine development, possible vaccine candidates, different vaccine strategies, safety evaluation issues, and vaccine production process pertaining to COVID-19 based on the knowledge acquired on SARS and MERS vaccine development in the past.