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Intraluminal Prucalopride Increases Propulsive Motor Activities in the Human Colon
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  • Mitra Shokrollahi,
  • Xuan-Yu Wang,
  • Natalija Milkova,
  • Jan Huizinga,
  • Ji-Hong Chen
Mitra Shokrollahi
McMaster University Faculty of Health Sciences
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Xuan-Yu Wang
McMaster University Faculty of Health Sciences
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Natalija Milkova
McMaster University Faculty of Health Sciences
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Jan Huizinga
McMaster University Faculty of Health Sciences
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Ji-Hong Chen
McMaster University Faculty of Health Sciences
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Abstract

High-resolution colonic manometry and biopsy immunohistochemistry revealed that 5-HT4 receptors in the lumen of the human colon are present exclusively on enterochromaffin cells and the 5-HT4 receptor agonist prucalopride, evokes all major propulsive motor patterns, associated with significant anal sphincter relaxation, when given intraluminally.