Protocol
A 90-minute recording of baseline activity was started 30 minutes after
the colonoscope was withdrawn. Afterwards, the response to a 5 min
balloon distention at the proximal colon was evaluated. A 1000 kcal meal
(500 g of organic vanilla yogurt fortified with organic milk fat
(Mapleton Organics, Moorefield, ON, Canada) was given and its effect was
observed for 90 min. Thereafter the effects of 2mg of prucalopride
(Resotran) given in the proximal colon via the catheter were observed
for 60 minutes. The prucalopride suspension was made in saline by
crushing a tablet with a pestle and mortar for 5 minutes and suspending
in 20 ml sterile water. Drug administration was followed by more water
to flush the drug delivery catheter. At the end of the study, an X-ray
was taken using a portable X-ray machine that was brought into the study
room. The catheter which was used in this patient contains radiopaque
markers which are visible under X-ray and were used to visualize the
placement of the catheter along the colon.