Luminal Prucalopride
Luminal administration of prucalopride in the proximal human colon
evoked powerful propulsive motor patterns and enhanced the amplitude of
simultaneous pressure waves compared to both baseline and after meal.
This response is similar to a typical response to luminal bisacodyl (37)
(4). The induction of vomiting is a known effect of mucosal 5-HT
receptor activation in the small bowel (48). The effect of prucalopride
is likely mediated by 5-HT4Rs on enterochromaffin cells
since we found an abundance of the 5-HT4R in the
epithelial layer of biopsies of this patient and 100% co-localization of
the receptor with 5-HT positive cells.