Multiplicity of Infection
Multiplicity of infection (MOI), determined by genotyping highly
polymorphic markers and counting the numbers of alleles in each
infection, is a proxy measure of the intensity of transmission. MOI in
all areas was lower in all areas post-LLIN distribution decreasing from
1.8 to 1.3 (p=0.0463 Mann Whitney U test) and 2.0 to 1.4 (p=0.0495 Mann
Whitney U test), respectively for P. falciparum and P.
vivax . This corresponds with a lower proportion of multiclonal
infections, except for P. falciparum in ESP in 2012-13 (Figure 1
and Table S1). Despite an increase in PCR prevalence of P. vivaxin Madang Province in 2014, few multiclonal infections were detected
(Figure 1 and Table S1).