CRISPR-Cas based bacterial adaptive immunity depends on RNA to direct the Cas endonuclease to detect and destroy the foreign nucleic acid. Since the first demonstration of the ability of Cas13a to cleave non-targeted RNA after recognizing and cleaving the targeted RNA template \cite{East_Seletsky_2016}, CRISPR-Cas platform like Cas12-DETECTR \cite{Chen_2018}, Cas14-DETECTR , Cas13-SHERLOCK are finding wide application in molecular diagnosis. While Cas13a recognizes RNA as a template strand, Cas14 recognizes ssDNA and Cas12 recognizes ds/ss DNA. The choice of any these molecular scissors depends on the needs of the end product. CRISPR-Cas technique has now widely used to detect human papillomavirus (Chen et al., 2018), ZIKA and also the 2020 pandemic Sars-CoV-2.