Figure 2 Diagram of renin-angiotensin- aldosterone system (RAAS) and the target of SARS-Cov-2.
In the diagram, there are two major axes in the RAAS: ACE/Ang Ⅱ/AT1R axis and ACE2/Ang (1-7)/Mas axis; ACE2 is the key modulator in the RAAS, which plays a key importance in maintaining blood pressure homeostasis, containing fluid and salt balance in mammals. However, ACE2 is the receptor for SARS-Cov-2 infection which may lead to the imbalance of RAAS, and subsequently activate the inflammation in various organ.