3.2 Laryngeal cancer
Laryngeal cancer is closely related to the human papillomaviruses HPV16
and HPV18. It occurs in laryngeal mucosal epithelial tissue, where is
causes a foreign body sensation in the throat, discomfort when
swallowing, pain in the throat, or an irritating cough accompanied by
blood in the sputum [61]. Song et al. [62] divided laryngeal
tumor tissue cells into categories of tumor cells, immune cells,
epithelial cells, fibroblasts, and endothelial cells by performing
single-cell sequencing. The data showed that keratinocyte-like tumor
cells highly expressed SPRR3 , SPRR1B , and SPRR1A ,
which are members of the SPRR family, and encode the specific markers
for keratinocyte and squamous epithelial cell differentiation. SCS
showed that SLAMF9 was specifically expressed in the non-immune cells of
a rare form of laryngeal chondrosarcoma, and this finding was verified
by immunohistochemistry [63]. Wang et al. [64] selected three
prognosis-related IRLs (BARX1-DT, KLHL7-DT, and LINC02154) by the
machine learning method, and used them to predict the prognosis, immune
infiltration status, and immunotherapy response of LSCC patients.