In this brief report we describe an extraordinary case of a pediatric patient with a history of medulloblastoma who developed an intracranial mass-like lesion during growth hormone treatment. To our knowledge this is the first case report of a mass-like lesion as a consequence of parenchymal fluid leakage adjacent to an intraventricular catheter due to increased intracranial pressure during growth hormone therapy which has been proven by biopsy.