Introduction
This project aimed to determine what genetic mutations (resulting from coding errors) could be responsible for the development of uveal melanoma. Within this study, genetic alterations resulting from chromosomal rearrangements were disregarded, but base pair mismatches causing missense, nonsense, or frameshift mutations were considered. Some patients had also experienced metastasis of cancerous cells through the bloodstream; data from their sample genomes were considered separately in an effort to identify any genetic mutations accelerating metastasis. The basic procedures for this study involve the comparison of a mutated DNA sequence (found in cancerous cells) with the matched normal sequence (found in healthy, unaffected cells).