Figure 1. Biocatalytic cascade for the synthesis of polycaprolactone monomers. The cascade is composed of a Cytochrome P450 monooxygenase (Cyp), a cyclohexanol dehydrogenase (CDH), and a cyclohexanone monooxygenase (CHMO) for the production of ε-caprolactone (ε-CL) [16]. Optionally, a lactonase (Lact) catalyzes the ring-opening reaction to yield 6-hydroxyhexanoic acid (6HA).