Figure legend
Figure 1. Dysregulation in lung epithelial metabolic pathways in
SARS-CoV2 infection. 1A) Heatmap depicting the number of shared as well
as exclusive significantly regulated genes, in the indicated cell lines
in response to infection with indicated viruses. The diagonal of the
heatmap represents the genes exclusively regulated only in the indicated
datasets. (Detail about dataset is described in supplementary data).1B,C) Circos plots depicting the upregulated (B) and
downregulated (C) enriched pathways that are exclusive to or
shared among the indicated datasets. Datasets are the same as described
in the legend of Fig 1A. 1D) Table shows the abbreviations and
their corresponding pathway designations.
Figure 2. Shared enrichment of metabolic pathways between
SARS-CoV2-infected and diabetic lung. 2A) Integrated analysis of the
HLEC transcriptome in response to SARS-CoV2 infection as well as a
COVID-19 bronchoalveolar lavage (BAL) and autopsied lung
transcriptomealong with lung transcriptome from two different datasets
of preclinical rodent models of diet-induced obesity and diabetes (DIOD
lung) was performed. 2B) Heatmap depicting the upregulation
(value 1) or downregulation (value -1) of selected pathways in the
indicated datasets. The heatmap was generated using the CIMMINER
software and unsupervised clustering using the correlation algorithm and
average linkage cluster method.