Comparison of NICE and FMF screening algorithms
Of the total cohort, 766 (12.8%) pregnancies were considered high risk for PE based on the NICE screening method, of which 577 (75.3%) were appropriately prescribed aspirin prophylaxis. Among the 24.7% who were screen positive and not prescribed aspirin, 75% had at least one major risk factor as described by the NICE recommendations. (Table 1)
Using a risk cut-off of ≥1:100, 950 (15.9%) pregnancies were considered high-risk based on the FMF algorithm. 391 (6.5%) of these pregnancies were also screen positive by NICE criteria. This resulted in a third of the women screening positive using the FMF algorithm receiving aspirin prophylaxis. In comparison to the NICE method, the FMF screening algorithm identified 87 additional pregnancies complicated by PE that may have benefitted from first trimester aspirin prophylaxis. (Table 1)