Materials and Method
The Ethics Committee’s approval of this study was taken from[removed for blind peer review] Ethics Committee with
the file number of 2018/716.
In this study, all patients who underwent open or transoral laser
surgery for laryngeal malignancies or biopsied for the suspicion of a
laryngeal malignancy in a tertiary university hospital’s Ear Nose Throat
and Head and Neck Surgery clinic between the years 2006 – 2017 were
evaluated.
All patients with pathology result other than vSCC (conventional SCC and
non-SCC laryngeal malignancies) were excluded from the study. A
retrospective chart analysis was made for all patients with a definite
vSCC pathology report including information of sex, age at the time of
diagnosis, localization of the primary lesion, TNM stage at the time of
diagnosis, primary treatment modality (surgery, radiotherapy (RT) or
chemoradiotherapy (CRT), adjuvant treatment modalities if available and
cause of death for the patients who died during the follow-up. Overall
survival, disease-free survival and overall follow-up period was
calculated as months.
Lastly, preoperative and postoperative pathology reports of surgically
treated patients were compared to analyze whether a difference exists
between preoperative results from small biopsy specimens and definite
pathology reports form the excision material.
Microsoft Excel Volume 15.31 (170216) and SPSS 21.0 programs were used
for the statistical analysis of the study. Kaplan – Meier analysis was
used for the survival analysis.