Statistical analyses
All data values are given as the mean ± standard error of mean (SEM), unless otherwise stated. Prior to statistical analysis, normality and outlier tests were conducted. For comparisons between multiple groups of data, one-way or two-way ANOVA with a 95% confidence interval was used followed by a post-hoc Tukey’s or Bonferroni’s test for multiple comparisons. When making direct comparisons between two paired measurements, a paired, two-tailed Student’s t-test was used.
Statistical analysis for the electrophysiology in theAPPNL-F/NL-F model and the immunofluorescence data was conducted using GraphPad Prism version 8.0.0 for Windows, GraphPad Software, San Diego, California USA, graphpad.
All statistical analyses were conducted using the statistical package Origin Pro 2016 SR1. Statistical significance was accepted wherep < 0.05 (*p < 0.05, ** p<0.01). The “n” are given as the number of observations and the number of animals used, unless otherwise stated.