Fig. 6. H & E staining of tumor sections under ×200 microscope.The interpretation was made by two pathologists which accounts for the color difference due to different microscopes used.
A1: SEC tumors showing cells with pleomorphism, hyperchromatism and high N/C ratio admixed with few areas of necrosis and apoptotic bodies.
A2: SEC tumors showing mitosis. A3: SEC tumors showing bizarre giant tumor cells.
B1: SEC-CDDP showing extensive areas of necrosis, however viable tumor cells could be detected.
B2: SEC-CDDP forming a vascular embolus.
C: SEC-indomethacin showing little effect of indomethacin with still viable tumor cells with few areas of necrosis.
D: SEC-combination showing extensive areas of necrosis [ghost cells] with no viable tumor cells
E1: SEC/CDDP showed very aggressive tumor cells with extensive mitosis, no necrosis or apoptotic bodies could be detected.
E2: A wide field of mitosis with pleomorphism in SEC/CDDP tumor sections.
E3: Perineural invasion in SEC/CDDP tumor tissues.
F: SEC/CDDP-indomethacin showing viable tumor cells with few areas of necrosis and apoptotic bodies
G: SEC/CDDP-combination showing extensive areas of necrosis [ghost cells] with very few viable tumor cells.
H: SEC/CDDP-CDDP showing extensive areas of necrosis, however, viable aggressive tumor cells could be detected.