Abstract Background As the coronavirus disease 2019 (COVID-19) spreads worldwide, the virus containment measures significantly affected the travel, work and live, which may bring negative impacts on the mental status of people, especially on patients. Measures This study take the spine surgery department as an example in The First Affiliated Hospital of Anhui Medical University in Hefei, Anhui, China. A psychological scale were constructed to assess the mental status of patients who were admitted to hospital during Jan 24 to Apr 2. The number of newly confirmed COVID-19 patients in Anhui, China were collected each day during Jan 24 to Apr 2. Results The mental status of patients were relatively poor at the beginning of the outbreaks and then gradually returned to normal. The trends between the psychological of patients and the number of newly confirmed COVID patients were similar. Conclusion The outbreaks adversely affected the mental state of spine patients, which showed a similar trend with the number of newly confirmed patients. However, the connection between them required further study to identify. This phenomenon may be widespread in spine surgery department and other departments, which required more attention.