Outcomes |
Non-insulin Users (n = 4094) |
Non-insulin Users (n = 4094) |
Non-insulin Users (n =
4094) |
Insulin Users (n = 2047) |
Insulin Users (n =
2047) |
Insulin Users (n = 2047) |
Crude HR (95% CI) |
p Value
|
Adjusted HR† (95%
CI) |
p Value
|
|
Events |
PY |
IR |
Events |
PY |
IR |
|
|
|
|
All-cause mortality |
979 |
24075 |
4.07 |
627 |
11866 |
5.28 |
1.33(1.21˗1.48) |
<0.0001 |
1.31(1.18˗1.45) |
<0.0001 |
HCC |
700 |
22490 |
3.11 |
402 |
10921 |
3.68 |
1.17(1.03˗1.32) |
0.01 |
1.18(1.05˗1.34) |
0.007 |
MACE |
512 |
22227 |
2.30 |
339 |
10738 |
3.16 |
1.37(1.19˗1.57) |
<0.0001 |
1.41(1.23˗1.62) |
<0.0001 |
Stroke |
300 |
23086 |
1.30 |
186 |
11285 |
1.65 |
1.28(1.07˗1.54) |
0.007 |
1.31(1.09˗1.58) |
0.004 |
Ischemic heart disease |
198 |
23277 |
0.85 |
128 |
11394 |
1.12 |
1.31(1.05˗1.64) |
0.02 |
1.36(1.09˗1.71) |
0.006 |
Heart failure
|
125
|
23649
|
0.53
|
128
|
11507
|
1.11
|
2.11(1.65˗2.71)
|
<0.0001
|
2.18(1.70˗2.80)
|
<0.0001
|
Decompensated cirrhosis |
642 |
22865 |
2.81 |
465 |
10890 |
4.27 |
1.50(1.33˗1.69) |
<0.0001 |
1.53(1.35˗1.72) |
<0.0001 |
Variceal bleeding
|
41
|
23986
|
0.17
|
38
|
11767
|
0.32
|
1.83(1.18˗2.85)
|
0.007
|
1.81(1.16˗2.83)
|
0.009
|
Hepatic ascites
|
407
|
23381
|
1.74
|
327
|
11196
|
2.92
|
1.66(1.43˗1.92)
|
<0.0001
|
1.68(1.45˗1.95)
|
<0.0001
|
Hepatic encephalopathy |
351 |
23577 |
1.49 |
281 |
11380 |
2.47 |
1.64(1.40˗1.91) |
<0.0001 |
1.63(1.39˗1.91) |
<0.0001 |
Jaundice |
102 |
23848 |
0.43 |
45 |
11757 |
0.38 |
0.88(0.62˗1.25) |
0.49 |
0.90(0.63˗1.29) |
0.58 |
Hepatic failure |
493 |
23363 |
2.11 |
388 |
11230 |
3.46 |
1.62(1.42˗1.85) |
<0.0001 |
1.26(1.42˗1.86) |
<0.0001 |
Hypoglycemia |
68 |
23893 |
0.28 |
107 |
11576 |
0.92 |
3.26(2.40˗4.42) |
<0.0001 |
3.33(2.45˗4.53) |
<0.0001 |