Introduction
Coronary artery bypass is one of the most widely performed adult cardiac surgical procedures. The most frequentlyemployed technique involvescardiopulmonary bypass (CPB) and cardioplegic arrest of the heart.Cardioplegia is a crucial myocardial protection technique for patients from all age groups requiring cardiac surgery necessitating cardiac arrest.A wide range of cardioplegia solutions is currently available for myocardial protection in cardiac surgery. Cardioplegia solutions broadly fall into two main types, based on the basic solutions that comprise the contents of blood and crystalloid cardioplegia. Blood-based cardioplegia solutions bear a close resemblance to normal physiological oxygen transport capacity and appear to be advantageous and involve fewer risks in terms of myocardial protection. In the early 1990s, Dr. Pedro del Nido and his team developed a solution known as “del Nidocardioplegia”. This wasoriginally employed for pediatric cardiac surgery, but has recently been employed in a single dose in adult cardiac surgery. del Nidosolution (DNS) can be used in a single dose, yielding a minimum of 90 minutes of cardiac arrest (1).
Only a few retrospective studies have investigated the use of DNScardioplegia in coronary artery bypass in adult patients (2-4).This randomized prospective study was therefore designed to determine the efficacy and safety profiles of DNS compared to IWBC in CABG surgery.