Authors' contribution CC, IB, SC, DF, DB, RI, MC, MS, CC conceptualized the idea and collected clinical data about patients, contributed to write and revise the paper. VB and MM performed laboratory assessments, GC e RDS performed statistical analysis of data. AG, GP, GWC, EH, and SDG critically revised the manuscript. All authors read and approved the final manuscript. Acknowledgements Thank you to Dr. Umberto Basile and Dr. Cecilia Napodano for the scientific support in performing laboratory assessments. Conflict of interest The authors declare no conflict of interest for this manuscript.