Sesame seed allergy
We included 9 studies on accuracy of diagnostic tests for sesame allergy. Seven studies for SPT [35, 76, 137, 145, 147, 148, 156] , 7 for sIgE [76, 120, 137, 145, 147, 148, 156], 3 for Ses i 1 [76, 120, 145]and 3 for BAT [35, 76, 148] met inclusion criteria for sesame allergy meta-analyses. SPT to sesame and sIgE to sesame showed pooled sensitivity of 70% each with a specificity of 89% and 83%, respectively. (Figure 2G)
Sensitivity increased in the 2–16-year age group for sIgE-sesame to 94% (Table 6 ). For studies done in the Middle East, specificity of SPT to sesame decreased to 69% (Table 7 ). For CRDs, Ses i 1 had a sensitivity of 77% with a specificity of 87%. BAT to sesame showed pooled sensitivity of 89% with a high specificity of 93% (Table 2) at a 10% cut-off. Studies on SPT to sesame and sIgE to sesame were more heterogeneous than those for BAT to sesame.
The maximum sensitivity was ≥ 90% for BAT to sesame and the maximum specificity was ≥ 90% for sIgE to sesame, BAT to sesame, and SPT to sesame (Tables S5 and S6 ).