Conclusion and future perspectives
In 21st century, COVID-19 is the most contagious pathogen and
challangeful pandemic worldwide. Vaccine promote our body to produce
antibody against targeted antigens most are helpful for preventive than
treatment. By April 2020, there is no licensed drug or vaccine against
COVI-19. Globally, more than 3 billion peoples are under quatrain,
unemployment rate is increasing and consequences world economic crises.
Very urgent vaccine and antibody development against COVID-19 is
necessary. We summarized our manuscript in the following key points. 1.
In order to slow down the fast spread, use a convalescent plasma therapy
as an immediate therapy from fully recovered COVID-19 patents.
2. O blood group individuals are not susceptible against COVID-19 as
compare non-O blood group. Convalescent plasma therapy taken from O
recovered individuals was shown good result for vulnerable people
eventually for risky pregnant woman. Hence, ABO blood group genes
involvement in related to COVID-19 outbreak further more study is
encouraged. 3. Potent neutralizing monoclonal antibody can be isolated
from EBV transformed immortal B cells of fully recovered COVID-19 O
blood group patient. 4. Histo‐blood group antigens which are responsible
for ABO blood group and COVID-19 are highly expressed on epithelial
cells of respiratory tracts. anti-A antibody containing plasma from O
blood and lab produced anti -A monoclonal antibody inhibited the
interaction of SARS Co-V S-protein and ACE2 host receptor.so that,
further study based on this may have effective results for COVID-19
vaccine design and antibody production.5. Identify the efficient RBD of
spiked glycoprotein of COVID-19. The domain which contains 318-510 amino
acid residues have targeted amino acid residues to express ACE2 and RBD
binding affinity hence, this domain based urgent vaccine and antibody
development is important.
COVID-19 lack the necessary machinery to self-replicate and it dependent
on the host cell machinery for propagation. Taking drastic prevention
and control methods by the individual community helps to slow down the
rapid COVID-19 pandemic and create a window time for the scientific
researchers to develop effective vaccine and antibody as long-term goal
is necessary.