Conclusion and future perspectives
In 21st century, COVID-19 is the most contagious pathogen and challangeful pandemic worldwide. Vaccine promote our body to produce antibody against targeted antigens most are helpful for preventive than treatment. By April 2020, there is no licensed drug or vaccine against COVI-19. Globally, more than 3 billion peoples are under quatrain, unemployment rate is increasing and consequences world economic crises. Very urgent vaccine and antibody development against COVID-19 is necessary. We summarized our manuscript in the following key points. 1. In order to slow down the fast spread, use a convalescent plasma therapy as an immediate therapy from fully recovered COVID-19 patents.
2. O blood group individuals are not susceptible against COVID-19 as compare non-O blood group. Convalescent plasma therapy taken from O recovered individuals was shown good result for vulnerable people eventually for risky pregnant woman. Hence, ABO blood group genes involvement in related to COVID-19 outbreak further more study is encouraged. 3. Potent neutralizing monoclonal antibody can be isolated from EBV transformed immortal B cells of fully recovered COVID-19 O blood group patient. 4. Histo‐blood group antigens which are responsible for ABO blood group and COVID-19 are highly expressed on epithelial cells of respiratory tracts. anti-A antibody containing plasma from O blood and lab produced anti -A monoclonal antibody inhibited the interaction of SARS Co-V S-protein and ACE2 host receptor.so that, further study based on this may have effective results for COVID-19 vaccine design and antibody production.5. Identify the efficient RBD of spiked glycoprotein of COVID-19. The domain which contains 318-510 amino acid residues have targeted amino acid residues to express ACE2 and RBD binding affinity hence, this domain based urgent vaccine and antibody development is important.
COVID-19 lack the necessary machinery to self-replicate and it dependent on the host cell machinery for propagation. Taking drastic prevention and control methods by the individual community helps to slow down the rapid COVID-19 pandemic and create a window time for the scientific researchers to develop effective vaccine and antibody as long-term goal is necessary.