Conclusion:
Our study results supported the data that performing CNS prophylaxis with triple intrathecal therapy in pediatric patients with ALL and early recognition of patients with a high probability of relapse with MRD follow-ups increase patient survival rates. However, improving treatment protocols and early detection of patients with a high probability of relapse alone are not sufficient to increase survival rates, especially in developing countries. In order to prevent deaths due to infections in LICs, it is necessary to take social and economic measures as well as medical studies.
Special thanks: The authors thank the esteemed Dr. C-H Pui for sharing your valuable opinions with us.