Results
We collected 12 articles on SARS -COV -2 and IAV co-infection from
PubMed, Web of Science and CNKI and excluded 6 studies for those that
did not include clinical information of patients. The remaining 6
articles (1 was clinical study and the other 5 were case reports)
provided us 11 cases with clinical information. Thus our cohort had 13
patients who suffered from both SARS -COV -2 and IAV co-infection in the
pandemic.(Azekawa, Namkoong, Mitamura, Kawaoka, & Saito, 2020;Ding et
al. 2020;Khodamoradi et al. 2020;Konala et al. 2020;Sha 2020;Wu et al.
2020) (Table 1).
In this descriptive study, 7 patients (53.8%) were severe cases, 7
(53.8%) were males,the median age was 50 years (IQR, 40.5-67.5). 5
patients (38.5%) had comorbidities such as
hypertension, diabetes, kidney
tumor, cerebrovascular disease, coronary artery disease, dyslipidemia,
hypothyroidism, pituitary microadenoma, congestive heart failure,
chronic kidney disease. The most common symptoms before admission were
cough (100%), fever (92.3%), dyspnea (76.9%) and
myalgia
(53.8%). Other symptoms such as fatigue, anorexia, headache, nasal
tampon, expectoration, pharyngalgia, diarrhea, chest pain and chill were
also seen in the cohort (Table 2).
On admission, 8 patients (61.5%) had decreased lymphocyte count, 6 of
10 patients (60%) had lower oxygen saturation (SpO2≤93%) on ambient
air. All the 13 patients (100%) had abnormal radiological changes in
their first examination after admission. The median time from symptom
onset to hospital admission was 4.5 days (IQR, 2.75-5.5), and the median
time of hospital stay was 17 days (IQR,15-20). Among the patients, 6 of
9 (66.7%) had oxygen inhalation, including 1 received noninvasive
ventilation, and 2 patients received endotracheal intubation in
the ICU. 8 of 9 patients (88.9%)
had oseltamivir treatment, and 7 of 8 patients (87.5%) had other
antiviral treatment except oseltamivir. 8 patients (100%) received
antibiotic therapy, only 3 of 8 (37.5%) were treated with
corticosteroids. 2 patients suffered from acute liver injury and 2
developed into acute respiratory distress syndrome during the clinical
course. 7 patients were discharged. The remaining 6 patients’ clinical
outcome were not available. (Table 3).