Results
We collected 12 articles on SARS -COV -2 and IAV co-infection from PubMed, Web of Science and CNKI and excluded 6 studies for those that did not include clinical information of patients. The remaining 6 articles (1 was clinical study and the other 5 were case reports) provided us 11 cases with clinical information. Thus our cohort had 13 patients who suffered from both SARS -COV -2 and IAV co-infection in the pandemic.(Azekawa, Namkoong, Mitamura, Kawaoka, & Saito, 2020;Ding et al. 2020;Khodamoradi et al. 2020;Konala et al. 2020;Sha 2020;Wu et al. 2020) (Table 1).
In this descriptive study, 7 patients (53.8%) were severe cases, 7 (53.8%) were males,the median age was 50 years (IQR, 40.5-67.5). 5 patients (38.5%) had comorbidities such as hypertension, diabetes, kidney tumor, cerebrovascular disease, coronary artery disease, dyslipidemia, hypothyroidism, pituitary microadenoma, congestive heart failure, chronic kidney disease. The most common symptoms before admission were cough (100%), fever (92.3%), dyspnea (76.9%) and myalgia (53.8%). Other symptoms such as fatigue, anorexia, headache, nasal tampon, expectoration, pharyngalgia, diarrhea, chest pain and chill were also seen in the cohort (Table 2).
On admission, 8 patients (61.5%) had decreased lymphocyte count, 6 of 10 patients (60%) had lower oxygen saturation (SpO2≤93%) on ambient air. All the 13 patients (100%) had abnormal radiological changes in their first examination after admission. The median time from symptom onset to hospital admission was 4.5 days (IQR, 2.75-5.5), and the median time of hospital stay was 17 days (IQR,15-20). Among the patients, 6 of 9 (66.7%) had oxygen inhalation, including 1 received noninvasive ventilation, and 2 patients received endotracheal intubation in the ICU. 8 of 9 patients (88.9%) had oseltamivir treatment, and 7 of 8 patients (87.5%) had other antiviral treatment except oseltamivir. 8 patients (100%) received antibiotic therapy, only 3 of 8 (37.5%) were treated with corticosteroids. 2 patients suffered from acute liver injury and 2 developed into acute respiratory distress syndrome during the clinical course. 7 patients were discharged. The remaining 6 patients’ clinical outcome were not available. (Table 3).