Lung biopsy
The findings of lung tissue histopathologic examination were similar to
DAD (diffused alveolar damage) with focally fibromyxoid exudate.
Interstitial and alveolar edema with foci of hyaline membranes and
fibrinous exudate.
Intra-alveolar hemorrhage, moderately interstitial inflammation with
composed of lymphocytes, plasma cells and neutrophils were seen. Focally
necrosis and alveolar destruction were present. The other important
findings are intravascular micro-thrombi and large multinuclated
pneumocytes with focal presence of intra-nuclear inclusion like
structure (may be due to viral cytopathic changes). Also desquamation of
pneumocytes was noted. There was no evidence of mucus plugging with in
airways. No granuloma or eosinophilic infiltrations were identified.
Histopathologic examination of Renal biopsy
Histopathologic findings mostly revealed mild acute tubulointerstitial
nephritis (ATIN) with subtle attenuation of tubular epithelium,
interstitial edema with mild lymphocytic infiltration. No granuloma and
cytophathic effect were identified. Vascular damage and arteriosclerosis
were not seen. Glomeruli were intact.