Lung biopsy
The findings of lung tissue histopathologic examination were similar to DAD (diffused alveolar damage) with focally fibromyxoid exudate. Interstitial and alveolar edema with foci of hyaline membranes and fibrinous exudate.
Intra-alveolar hemorrhage, moderately interstitial inflammation with composed of lymphocytes, plasma cells and neutrophils were seen. Focally necrosis and alveolar destruction were present. The other important findings are intravascular micro-thrombi and large multinuclated pneumocytes with focal presence of intra-nuclear inclusion like structure (may be due to viral cytopathic changes). Also desquamation of pneumocytes was noted. There was no evidence of mucus plugging with in airways. No granuloma or eosinophilic infiltrations were identified.
Histopathologic examination of Renal biopsy
Histopathologic findings mostly revealed mild acute tubulointerstitial nephritis (ATIN) with subtle attenuation of tubular epithelium, interstitial edema with mild lymphocytic infiltration. No granuloma and cytophathic effect were identified. Vascular damage and arteriosclerosis were not seen. Glomeruli were intact.