Materials and Methods
Our study is a cross-sectional, case-control study. The local ethical committee approved this study. Patients between the ages of 18 and 50 admitted to the emergency department with hypoglycemia symptoms and whose blood glucose was 70 and below were included in the study. The fasting routine blood samples were investigated by examining these patients’ internal medicine-endocrinology department records after their emergency room administration. Hypoglycemia patients whose cardiology application was recommended mainly due to palpitation symptoms, dizziness, and presyncope, were evaluated in terms of essential echocardiographic evaluation, tissue doppler, and flow-mediated dilatation.
Patients diagnosed with diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, congestive heart failure, peripheral artery disease, moderate to severe heart valve disease, cardiomyopathies, thyroid dysfunction, chronic obstructive pulmonary disease, malignancy, rheumatological disease, active infection, kidney failure, liver disease, obesity (body mass index >30), drug usage(including beta-blockers), and patients with heavy alcohol intake and smoking were excluded from the study. A total of 46 patients were included in the survey by excluding patients with low echogenicity who were not suitable for imaging. Thirty healthy individuals who were not diagnosed with hypoglycemia before were included in the study as the control group.
The HOMA-IR is being used extensively for estimates of beta-cell function and insulin resistance and calculated with the formula ’(Fasting insulin in mIU/L * fasting blood glucose in mg/dL) / 405’. A HOMA-IR value of 2.5 and above was accepted as insulin resistance (21).
The groups with and without insulin resistance were determined based on the HOMA-IR scores of the patient group, and it was evaluated whether the differences with the control group were related to insulin resistance.