Data collection
A clinical history revision of the included patients was performed, focusing mainly at patients’ consulting disease, comorbidities and the treatments being currently followed by them (Supplementary Table 1 and Supplementary Table 2 ). Briefly, diabetes, pulmonary disease, cardiovascular (CV) disease and chronic kidney disease were registered if they were present in the clinical history. In the case of arterial hypertension (AHT) and transplantation, they were only recorded if patients were receiving treatment with specific drugs for those comorbidities. Finally, cancer was recorded only if the patient had an active process or was following a treatment for a previous cancer, during the studied period.
The primary outcome was the presence of confirmed or highly suspected symptomatology of COVID-19 (hsCOVID-19) informed both at the hospital or at the primary care centre, from the 1st to the 29th of March 2020. Following the Spanish health authorities’ recommendation for the identification in primary care centres of patients with unconfirmed symptoms of SARS-CoV-2 infection, it was considered that patients presented symptoms when they reported fever (defined as axillary temperature >37ºC) and shortness of breath and/or cough. If only fever was present, it was only considered as symptoms if it came with at least two of the following symptoms: anosmia, ageusia, rhinorrhea, diarrhea of one week of evolution, pharyngitis, odynophagia or arthromyalgia.