Author contribution statement
ES, DC, EC and AGC carried out the experiments and data collection. ES and BD recruited the patients. ES and AS performed the statistical analysis. ES, DC and RP conceived the study and assisted in data interpretation. All authors reviewed, edited and approved the final manuscript.
All Authors consent for publication, and confirm that this manuscript is original, has not been published before, is not currently being considered for publication elsewhere, and has not been posted to a preprint server.