Laboratory testing in infants with neurologic
abnormalities potentially related to congenital ZIKV infection
A total of 16/19(84.2%) infants were tested for other congenital
infections and were negative for enterovirus (10), parvovirus (12),
HSV-I (13), HSV-II (13), and HHV-6 (4). Two dichorionic twins had CMV
infection and received antiviral treatment.
Anti-ZIKV IgM was done in 14/17(82.4%) infants who survived with
features potentially related to ZIKV infection. Of these, only four
(28.6%) were positive. One had a previous positive ZIKV-PCR in amniotic
fluid, and two had a positive ZIKV-RNA PCR in necropsy
tissues26. Only five of these infants were submitted
to ZIKV-RNA testing in serum, but no positive test was identified. Thus,
congenital ZIKV infection could be laboratory-confirmed in only
7/17(41.2%) infants (Table 2 footnotes).