Statistical analysis
Data were generally not normally distributed. Comparisons between groups
were undertaken using Kruskal-Wallis, Mann-Whitney, Fishers-Exact Test,
Analysis of Variance on Ranks, and Repeated Measures Analysis of
Variance on Ranks as appropriate using GraphPad Prism 7.0 (GraphPad
Inc., La Jolla, CA, USA) or SigmaPlot V13 (Systat Software Inc. San
Jose, CA, USA). Statistical significance was accepted at the 5% level.