FIGURE LEGENDS
Figure 1. Family genogram for RYR1 (NM 001042723) mutations.The patient’s mother and third sister were confirmed to have homologous
gene mutations, while his father as well as eldest sister and second
sister did not find the same mutations in genetic testing.
Fig.2 The goodness of fit between predicted and measured
dantrolene plasma concentration (ng/ml). According to the United States
MHAUS guidelines (the first bolus as 2.5 mg/kg dantrolene, and 1 mg/kg
bolus every 6 h then), predicted concentrations were calculated with the
reported population PK model (4) and didn’t match well with the measured
concentrations over the entire concertation range after PE.