Contributions
X-x Li was responsible for designing sampling strategies, collecting samples, calculating PK parameters, and drafting the manuscript. C Li was responsible for the treatment decision, collecting clinical data, and involved in drafting the manuscript. Y Zhou and B Han were responsible for offering clinical data and revising the manuscript. X Xiong was responsible for establishing a measuring method of plasma concentrations. C-h Wang was involved in calculating PK parameters and revising the manuscript. C-y Zhou was responsible for the plasma concentrations of dantrolene determination. L Yang was responsible for the access to dantrolene, checking sampling strategies and measured data, and approving the final version of the manuscript. X-y Guo was responsible for the treatment decision, the access to dantrolene, getting informed consent from parents, and approving the final version of the manuscript.