Post-Transplant Outcomes
The post-transplant outcomes were compared across weight categories. The
rates of mild acute GVHD (grade 0-2) were 83.3%, 83.5%, 84.4%, and
74.4% and the rates of severe acute GVHD (grade 3-4) were 16.7%,
16.5%, 15.6%, and 25.6% for individuals in the UW, NW, OW, and OB
weight categories respectively (p = 0.54) (Table 3). The rates of
0-limited chronic GVHD were 83.3%, 92.2%, 88.1%, and 94.4%, while
the rates for moderate-severe chronic GVHD were 16.7%, 7.8%, 11.9%,
and 5.6% for individuals in the UW, NW, OW, and OB weight categories
respectively (p = 0.48). Individuals in the UW, NW, OW and OB
weight categories did not demonstrate statistically significant
differences in rates of viral infections (p = 0.37), time to
platelet engraftment (p = 0.99), time to neutrophil engraftment
(p = 0.88), or 5-year survival (p = 0.32).
Cox proportional hazards models estimated the hazard ratios for
engraftment and overall survival. The hazard ratios for time to platelet
engraftment were not significantly different when comparing patients in
the OW category (HR 1.325, 95% CI 0.883 – 1.986, p = 0.174) and
OB category (HR 1.205, 95% CI 0.799 – 1.818, p = 0.374) versus
individuals in the NW/UW category. The hazard ratios for time to
neutrophil engraftment were not significantly different when comparing
patients who were OW (HR 1.238, 95% CI 0.885 – 1.731, p =
0.213) and OB (HR 0.878, 95% CI 0.593 – 1.298, p = 0.513) with
NW/UW patients. The hazard ratios for overall survival for individuals
in the OW weight category (HR 1.317, 95% CI 0.739 – 2.348, p =
0.351) and OB category (HR 1.072, 95% CI 0.576 – 1.994, p =
0.827) showed no significant differences compared with those who were
NW/UW. The Kaplan-Meier plot of overall survival probability showed
trends of worsened survival in OW and OB individuals compared with NW/UW
individuals, though not significant (p = 0.377) (Figure 2).