Post-Transplant Outcomes
The post-transplant outcomes were compared across weight categories. The rates of mild acute GVHD (grade 0-2) were 83.3%, 83.5%, 84.4%, and 74.4% and the rates of severe acute GVHD (grade 3-4) were 16.7%, 16.5%, 15.6%, and 25.6% for individuals in the UW, NW, OW, and OB weight categories respectively (p = 0.54) (Table 3). The rates of 0-limited chronic GVHD were 83.3%, 92.2%, 88.1%, and 94.4%, while the rates for moderate-severe chronic GVHD were 16.7%, 7.8%, 11.9%, and 5.6% for individuals in the UW, NW, OW, and OB weight categories respectively (p = 0.48). Individuals in the UW, NW, OW and OB weight categories did not demonstrate statistically significant differences in rates of viral infections (p = 0.37), time to platelet engraftment (p = 0.99), time to neutrophil engraftment (p = 0.88), or 5-year survival (p = 0.32).
Cox proportional hazards models estimated the hazard ratios for engraftment and overall survival. The hazard ratios for time to platelet engraftment were not significantly different when comparing patients in the OW category (HR 1.325, 95% CI 0.883 – 1.986, p = 0.174) and OB category (HR 1.205, 95% CI 0.799 – 1.818, p = 0.374) versus individuals in the NW/UW category. The hazard ratios for time to neutrophil engraftment were not significantly different when comparing patients who were OW (HR 1.238, 95% CI 0.885 – 1.731, p = 0.213) and OB (HR 0.878, 95% CI 0.593 – 1.298, p = 0.513) with NW/UW patients. The hazard ratios for overall survival for individuals in the OW weight category (HR 1.317, 95% CI 0.739 – 2.348, p = 0.351) and OB category (HR 1.072, 95% CI 0.576 – 1.994, p = 0.827) showed no significant differences compared with those who were NW/UW. The Kaplan-Meier plot of overall survival probability showed trends of worsened survival in OW and OB individuals compared with NW/UW individuals, though not significant (p = 0.377) (Figure 2).