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Risk factors associated with occurrence of COVID-19 among household persons exposed to patients with confirmed COVID-19 in Qingdao Municipal, China
  • +4
  • Hualei Xin,
  • Fachun Jiang,
  • Aili Xue,
  • Jiwei Liang,
  • Jingfei Zhang,
  • Feng Yang,
  • Yalin Han
Hualei Xin
Qingdao Municipal Center for Disease Control and Prevention
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Fachun Jiang
Qingdao Municipal Center for Disease Control and Prevention
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Aili Xue
Qingdao Women and Children's Hospital
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Jiwei Liang
Qingdao Municipal Center for Disease Control and Prevention
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Jingfei Zhang
Qingdao Municipal Center for Disease Control and Prevention
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Feng Yang
Qingdao Municipal Center for Disease Control and Prevention
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Yalin Han
Qingdao Municipal Center for Disease Control and Prevention
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Peer review status:Published

31 May 2020Submitted to Transboundary and Emerging Diseases
02 Jun 2020Submission Checks Completed
02 Jun 2020Assigned to Editor
06 Jun 2020Reviewer(s) Assigned
06 Jul 2020Review(s) Completed, Editorial Evaluation Pending
07 Jul 2020Editorial Decision: Revise Major
09 Jul 20201st Revision Received
13 Jul 2020Submission Checks Completed
13 Jul 2020Assigned to Editor
14 Jul 2020Review(s) Completed, Editorial Evaluation Pending
14 Jul 2020Editorial Decision: Accept
20 Jul 2020Published in Transboundary and Emerging Diseases. 10.1111/tbed.13743

Abstract

Tracing and isolation of close contacts is used to control outbreaks of coronavirus disease 2019 (COVID-19) in China. However, risk factors associated with occurrence of COVID-19 among close contacts have not been well described. 106 household contacts were included in this study, of whom 19 were developed into COVID-19 cases and the secondary attack rate was 17.9%. Multivariable analysis showed increasing risk of occurrence of COVID-19 among household contacts associated with female of index patients (Adjusted Hazard Ratio [aHR] = 5.61, 95%CI = 1.51-20.83), critical disease of index patients ([aHR] = 7.58, 95%CI = 1.66-34.66), effective contact duration with index patients >2 days ([aHR] = 4.21, 95%CI = 1.29-13.73), and effective contact duration >11 days ([aHR] = 17.88, 95%CI = 3.26-98.01).The sex and disease severity of index COVID-19 patients, and longer effective contact duration with COVID-19 confirmed cases could help epidemiologists to identify potential COVID-19 case among household contacts at an early stage.