2.10 Clinical verification
Femoral head samples were collected from 20 patients with OA and set-matched biopsies in 20 patients who had joint replacement surgery caused by femoral neck fracture at Wuhan Union Hospital, Huazhong University of Science and Technology. This study was approved by the Medical Ethics Committee of Huazhong University of Science and Technology Tongji Medicine College under protocol number (2019) IEC (S531). Written informed consent was obtained from each participant prior to sample collection, and all experiments were performed in accordance with relevant guidelines and regulations. The following inclusion criteria were used: Osteoarthritis was diagnosed according to the American rheumatology association’s diagnostic criteria and WOMAC scale. And the control group was selected patients with joint replacement surgery caused by femoral neck fracture excluded joint lesions caused by gout, rheumatoid arthritis, steroid-induced necrosis and alcohol-induced necrosis. The informed consent form was in the Supporting Information.
Results