2.10 Clinical verification
Femoral head samples were collected from 20 patients with OA and
set-matched biopsies in 20 patients who had joint replacement surgery
caused by femoral neck fracture at Wuhan Union Hospital, Huazhong
University of Science and Technology. This study was approved by the
Medical Ethics Committee of Huazhong University of Science and
Technology Tongji Medicine College under protocol number (2019) IEC
(S531). Written informed consent was obtained from each participant
prior to sample collection, and all experiments were performed in
accordance with relevant guidelines and regulations. The following
inclusion criteria were used: Osteoarthritis was diagnosed according to
the American rheumatology association’s diagnostic criteria and WOMAC
scale. And the control group was selected patients with joint
replacement surgery caused by femoral neck fracture excluded joint
lesions caused by gout, rheumatoid arthritis, steroid-induced necrosis
and alcohol-induced necrosis. The informed consent form was in the
Supporting Information.
Results