1.
|
Van Vliet et al27
|
Pediatric, AML
|
9
|
PCR
|
Decrease in Shannon index even prior to initiation of chemotherapy
Decrease in all genus with chemotherapy (Clostridium,
Bacteroides, Bifidobacterium)
Increase in Enterococcus
Partial recovery during subsequent cycle of chemotherapy
|
2.
|
Huang et al37
|
Pediatric, ALL
|
36 patients
36 controls
|
PCR
|
Lower total bacterial counts, lower Bifidobacteria,
Lactobacilli and E. coli than healthy controls prior to
chemotherapy
Further fall in bacterial counts, Bifidobacteria, Lactobacilli
and E. coli after high dose methotrexate
|
3
|
Stringer et al28
|
Adults
|
16 patients
|
PCR
|
Decrease in Bacteroides, Lactobacilli and
Bifidobacterium
Increase in E. coli and Staphylococci
|
4.
|
Rajagopala et al36
|
Children and young adults
|
28 patients
23 healthy controls
|
PCR
|
Lower Shannon index in patients
Lower Lachnospaerae, higher Bacteroides than healthy
controls
No change in Shannon index post chemotherapy, but increased
subsequently
|
5.
|
Montassier et al24
|
Adults with NHL for HSCT
|
8 patients
|
PCR
|
Decrease in Shannon index after starting chemotherapy
Increase in Bacteroides, decrease in Fermecutes and
Bifidobacterium
|
6
|
Zwielehner et al25
|
Adults
|
17 patients
|
PCR
|
Decrease in total bacterial count and diversity after starting
chemotherapy
Increase in Bacteroides and Clostridium cluster IV
Decrease in Bifidobacterium and Clostridium cluster IVa
|
7
|
Bamole VD et al38
|
Adult,
Ca colon
|
8 patients, 16 controls
|
Culture and PCR
|
Higher Bacteroides: Firmicutes ratio in patients
Lactobacillus not grown in any patient, 57% in controls
Dietary variation observed
|
8
|
Chua LL et al26
|
Pediatric;
ALL
|
7 patients
|
PCR
|
Decrease in alpha diversity even prior to initiation of chemotherapy
Relative decrease in firmicutes and abundance of Bacteroides prior to
therapy
The difference diminished after completion of therapy, but didn’t
normalise
|
9
|
Index study
|
Pediatric
|
-NEC: 38
-Non-NEC: 21
-Healthy controls: 30
|
Culture methods
|
Increase in Bacteroides and decrease in Lactobacilli in
NEC group
Trend towards higher isolation of Clostridium in NEC group
|