Discussion
The results of our longitudinal analyses in 631 children from the city
of Leipzig, Germany, show that
early life residence in places
with many trees and allergenic trees specifically, was consistently
associated with increased prevalence of AR up to 15 years and, to a
lesser extent, also with increased prevalence of allergic sensitization
to aeroallergens. Associations with asthma and sensitization to food
allergens were inconsistent. Associations with greenness, as measured by
NDVI, were either inconclusive (for asthma) or mostly non-significant
(for other outcomes). Effect estimates for trees and allergenic trees
and AR tended to be stronger in high NO2 and low ozone
settings.